/* ============================================
   Variables CSS
   ============================================ */
:root {
    /* Couleurs principales */
    --primary-color: #2563eb;
    --primary-dark: #1d4ed8;
    --primary-light: #60a5fa;
    
    /* Couleurs de statut */
    --success-color: #10b981;
    --warning-color: #f59e0b;
    --danger-color: #ef4444;
    --info-color: #3b82f6;
    
    /* Couleurs de texte */
    --text-primary: #1f2937;
    --text-secondary: #6b7280;
    --text-light: #9ca3af;
    
    /* Couleurs de fond */
    --bg-primary: #ffffff;
    --bg-secondary: #f9fafb;
    --bg-tertiary: #f3f4f6;
    
    /* Bordures */
    --border-color: #e5e7eb;
    --border-radius: 12px;
    --border-radius-sm: 8px;
    
    /* Ombres */
    --shadow-sm: 0 1px 2px 0 rgba(0, 0, 0, 0.05);
    --shadow-md: 0 4px 6px -1px rgba(0, 0, 0, 0.1);
    --shadow-lg: 0 10px 15px -3px rgba(0, 0, 0, 0.1);
    --shadow-xl: 0 20px 25px -5px rgba(0, 0, 0, 0.1);
    
    /* Espacements */
    --spacing-xs: 0.5rem;
    --spacing-sm: 1rem;
    --spacing-md: 1.5rem;
    --spacing-lg: 2rem;
    --spacing-xl: 3rem;
    
    /* Typographie */
    --font-family: 'Inter', -apple-system, BlinkMacSystemFont, 'Segoe UI', sans-serif;
    --font-size-xs: 0.75rem;
    --font-size-sm: 0.875rem;
    --font-size-base: 1rem;
    --font-size-lg: 1.125rem;
    --font-size-xl: 1.25rem;
    --font-size-2xl: 1.5rem;
    --font-size-3xl: 1.875rem;
    --font-size-4xl: 2.25rem;
}

/* ============================================
   Reset et Base
   ============================================ */
* {
    margin: 0;
    padding: 0;
    box-sizing: border-box;
}

html {
    scroll-behavior: smooth;
}

body {
    font-family: var(--font-family);
    font-size: var(--font-size-base);
    line-height: 1.6;
    color: var(--text-primary);
    background-color: var(--bg-secondary);
    overflow-x: hidden;
}

/* ============================================
   Container
   ============================================ */
.container {
    max-width: 1400px;
    margin: 0 auto;
    padding: 0 var(--spacing-md);
}

/* ============================================
   Header
   ============================================ */
.header {
    background: linear-gradient(135deg, #667eea 0%, #764ba2 100%);
    color: white;
    padding: var(--spacing-xl) 0;
    box-shadow: var(--shadow-lg);
    position: sticky;
    top: 0;
    z-index: 100;
}

.header-content {
    text-align: center;
}

.header h1 {
    font-size: var(--font-size-4xl);
    font-weight: 700;
    margin-bottom: var(--spacing-sm);
    display: flex;
    align-items: center;
    justify-content: center;
    gap: var(--spacing-md);
}

.header h1 i {
    font-size: 3rem;
    animation: heartbeat 1.5s ease-in-out infinite;
}

@keyframes heartbeat {
    0%, 100% { transform: scale(1); }
    25% { transform: scale(1.1); }
    50% { transform: scale(1); }
}

.subtitle {
    font-size: var(--font-size-lg);
    opacity: 0.95;
    font-weight: 300;
}

/* ============================================
   Navigation
   ============================================ */
.main-nav {
    background-color: var(--bg-primary);
    box-shadow: var(--shadow-md);
    position: sticky;
    top: 0;
    z-index: 99;
}

.nav-list {
    display: flex;
    list-style: none;
    justify-content: center;
    flex-wrap: wrap;
    gap: var(--spacing-xs);
    padding: var(--spacing-sm) 0;
}

.nav-link {
    display: flex;
    align-items: center;
    gap: var(--spacing-xs);
    padding: var(--spacing-sm) var(--spacing-lg);
    color: var(--text-secondary);
    text-decoration: none;
    font-weight: 500;
    border-radius: var(--border-radius);
    transition: all 0.3s ease;
    position: relative;
}

.nav-link:hover {
    background-color: var(--bg-tertiary);
    color: var(--primary-color);
    transform: translateY(-2px);
}

.nav-link.active {
    background-color: var(--primary-color);
    color: white;
    box-shadow: var(--shadow-md);
}

.nav-link i {
    font-size: 1.2rem;
}

/* ============================================
   Main Content
   ============================================ */
.main-content {
    padding: var(--spacing-xl) 0;
    min-height: 100vh;
}

.section {
    display: none;
    animation: fadeIn 0.5s ease-in;
}

.section.active {
    display: block;
}

@keyframes fadeIn {
    from {
        opacity: 0;
        transform: translateY(20px);
    }
    to {
        opacity: 1;
        transform: translateY(0);
    }
}

.section-header {
    text-align: center;
    margin-bottom: var(--spacing-xl);
    padding-bottom: var(--spacing-lg);
    border-bottom: 3px solid var(--primary-color);
}

.section-header h2 {
    font-size: var(--font-size-3xl);
    color: var(--text-primary);
    margin-bottom: var(--spacing-sm);
    display: flex;
    align-items: center;
    justify-content: center;
    gap: var(--spacing-md);
}

.section-header h2 i {
    color: var(--primary-color);
    font-size: 2.5rem;
}

.section-subtitle {
    font-size: var(--font-size-lg);
    color: var(--text-secondary);
    font-weight: 300;
}

/* ============================================
   Introduction Section
   ============================================ */
.intro-grid {
    display: grid;
    grid-template-columns: repeat(auto-fit, minmax(300px, 1fr));
    gap: var(--spacing-lg);
    margin-bottom: var(--spacing-xl);
}

.intro-card {
    background: white;
    padding: var(--spacing-lg);
    border-radius: var(--border-radius);
    box-shadow: var(--shadow-md);
    transition: transform 0.3s ease, box-shadow 0.3s ease;
}

.intro-card:hover {
    transform: translateY(-5px);
    box-shadow: var(--shadow-xl);
}

.card-icon {
    width: 80px;
    height: 80px;
    border-radius: 50%;
    display: flex;
    align-items: center;
    justify-content: center;
    margin: 0 auto var(--spacing-md);
}

.card-icon i {
    font-size: 2.5rem;
    color: white;
}

.intro-card h3 {
    text-align: center;
    font-size: var(--font-size-xl);
    color: var(--text-primary);
    margin-bottom: var(--spacing-md);
}

.intro-card p {
    text-align: center;
    color: var(--text-secondary);
    line-height: 1.8;
}

.key-phases {
    list-style: none;
    padding: 0;
}

.key-phases li {
    display: flex;
    align-items: center;
    gap: var(--spacing-sm);
    padding: var(--spacing-sm);
    margin-bottom: var(--spacing-xs);
    border-left: 3px solid var(--success-color);
    background-color: var(--bg-secondary);
    border-radius: var(--border-radius-sm);
}

.key-phases li i {
    color: var(--success-color);
    font-size: 1.2rem;
}

.sca-types {
    display: flex;
    justify-content: center;
    gap: var(--spacing-sm);
    flex-wrap: wrap;
    margin-top: var(--spacing-md);
}

.badge {
    padding: var(--spacing-xs) var(--spacing-md);
    border-radius: 20px;
    font-weight: 600;
    font-size: var(--font-size-sm);
    display: inline-block;
}

.badge-danger {
    background-color: #fee2e2;
    color: #991b1b;
}

.badge-warning {
    background-color: #fef3c7;
    color: #92400e;
}

.badge-info {
    background-color: #dbeafe;
    color: #1e40af;
}

/* Définitions */
.key-definitions {
    background: white;
    padding: var(--spacing-xl);
    border-radius: var(--border-radius);
    box-shadow: var(--shadow-md);
    margin-top: var(--spacing-xl);
}

.key-definitions h3 {
    font-size: var(--font-size-2xl);
    color: var(--text-primary);
    margin-bottom: var(--spacing-lg);
    display: flex;
    align-items: center;
    gap: var(--spacing-sm);
}

.definition-grid {
    display: grid;
    gap: var(--spacing-lg);
}

.definition-item {
    padding: var(--spacing-lg);
    background-color: var(--bg-secondary);
    border-left: 4px solid var(--primary-color);
    border-radius: var(--border-radius-sm);
}

.definition-item strong {
    display: block;
    font-size: var(--font-size-lg);
    color: var(--primary-color);
    margin-bottom: var(--spacing-sm);
}

.definition-item p {
    color: var(--text-secondary);
    line-height: 1.8;
}

/* ============================================
   Flowchart Styles
   ============================================ */
.flowchart-container {
    background: white;
    padding: var(--spacing-xl);
    border-radius: var(--border-radius);
    box-shadow: var(--shadow-md);
    margin-bottom: var(--spacing-xl);
}

.flowchart-title {
    font-size: var(--font-size-2xl);
    color: var(--text-primary);
    margin-bottom: var(--spacing-lg);
    text-align: center;
    display: flex;
    align-items: center;
    justify-content: center;
    gap: var(--spacing-sm);
}

.flowchart {
    display: flex;
    flex-direction: column;
    align-items: center;
    gap: var(--spacing-md);
}

.flow-step {
    width: 100%;
    max-width: 600px;
    padding: var(--spacing-lg);
    border-radius: var(--border-radius);
    box-shadow: var(--shadow-md);
    transition: all 0.3s ease;
    cursor: pointer;
}

.flow-step:hover {
    transform: scale(1.02);
    box-shadow: var(--shadow-lg);
}

.start-step {
    background: linear-gradient(135deg, #667eea 0%, #764ba2 100%);
    color: white;
}

.process-step {
    background: linear-gradient(135deg, #4facfe 0%, #00f2fe 100%);
    color: white;
}

.critical-step {
    background: linear-gradient(135deg, #fa709a 0%, #fee140 100%);
    color: white;
    border: 3px solid #ef4444;
}

.warning-step {
    background: linear-gradient(135deg, #fdeb71 0%, #f8d800 100%);
    color: #333;
}

.step-content {
    text-align: center;
}

.step-content i {
    font-size: 2.5rem;
    margin-bottom: var(--spacing-sm);
    display: block;
}

.step-content h4 {
    font-size: var(--font-size-xl);
    margin-bottom: var(--spacing-sm);
}

.step-content ul {
    text-align: left;
    list-style: none;
    padding: 0;
    margin-top: var(--spacing-md);
}

.step-content ul li {
    padding: var(--spacing-xs) 0;
    display: flex;
    align-items: center;
    gap: var(--spacing-sm);
}

.step-content ul li::before {
    content: "✓";
    font-weight: bold;
}

.flow-arrow {
    font-size: 2rem;
    color: var(--primary-color);
    animation: bounce 2s infinite;
}

@keyframes bounce {
    0%, 100% { transform: translateY(0); }
    50% { transform: translateY(10px); }
}

.flow-decision {
    width: 100%;
    max-width: 400px;
    padding: var(--spacing-lg);
    background: linear-gradient(135deg, #f093fb 0%, #f5576c 100%);
    color: white;
    border-radius: 50px;
    box-shadow: var(--shadow-lg);
    text-align: center;
}

.decision-content i {
    font-size: 2rem;
    margin-bottom: var(--spacing-sm);
}

.flow-branches {
    display: grid;
    grid-template-columns: repeat(auto-fit, minmax(300px, 1fr));
    gap: var(--spacing-lg);
    width: 100%;
    margin-top: var(--spacing-lg);
}

.branch {
    position: relative;
}

.branch-label {
    background-color: var(--primary-color);
    color: white;
    padding: var(--spacing-sm);
    border-radius: var(--border-radius-sm);
    text-align: center;
    font-weight: 600;
    margin-bottom: var(--spacing-md);
}

.btn-expand {
    margin-top: var(--spacing-md);
    padding: var(--spacing-sm) var(--spacing-lg);
    background-color: rgba(255, 255, 255, 0.2);
    color: white;
    border: 2px solid white;
    border-radius: var(--border-radius);
    cursor: pointer;
    font-weight: 600;
    transition: all 0.3s ease;
    display: flex;
    align-items: center;
    gap: var(--spacing-sm);
    margin-left: auto;
    margin-right: auto;
}

.btn-expand:hover {
    background-color: white;
    color: var(--primary-color);
    transform: translateY(-2px);
}

.time-critical {
    display: flex;
    align-items: center;
    justify-content: center;
    gap: var(--spacing-sm);
    margin-top: var(--spacing-md);
    padding: var(--spacing-sm);
    background-color: rgba(239, 68, 68, 0.2);
    border-radius: var(--border-radius-sm);
    animation: pulse 2s infinite;
}

@keyframes pulse {
    0%, 100% { opacity: 1; }
    50% { opacity: 0.7; }
}

/* ============================================
   Detail Sections (Collapsible)
   ============================================ */
.detail-section {
    background: white;
    border-radius: var(--border-radius);
    box-shadow: var(--shadow-lg);
    margin-bottom: var(--spacing-xl);
    overflow: hidden;
    max-height: 5000px;
    transition: max-height 0.5s ease, opacity 0.5s ease;
}

.detail-section.collapsed {
    max-height: 0;
    opacity: 0;
    margin-bottom: 0;
}

.detail-header {
    background: linear-gradient(135deg, #667eea 0%, #764ba2 100%);
    color: white;
    padding: var(--spacing-lg);
    display: flex;
    justify-content: space-between;
    align-items: center;
}

.detail-header h3 {
    font-size: var(--font-size-2xl);
    display: flex;
    align-items: center;
    gap: var(--spacing-sm);
}

.btn-collapse {
    background: rgba(255, 255, 255, 0.2);
    border: 2px solid white;
    color: white;
    padding: var(--spacing-sm) var(--spacing-md);
    border-radius: var(--border-radius);
    cursor: pointer;
    font-size: var(--font-size-lg);
    transition: all 0.3s ease;
}

.btn-collapse:hover {
    background: white;
    color: var(--primary-color);
}

/* ============================================
   Timeline Styles
   ============================================ */
.timeline-container {
    padding: var(--spacing-xl);
}

.timeline-item {
    display: flex;
    gap: var(--spacing-lg);
    margin-bottom: var(--spacing-xl);
    position: relative;
}

.timeline-item::before {
    content: '';
    position: absolute;
    left: 30px;
    top: 60px;
    bottom: -30px;
    width: 3px;
    background: linear-gradient(to bottom, var(--primary-color), var(--primary-light));
}

.timeline-item:last-child::before {
    display: none;
}

.timeline-marker {
    width: 60px;
    height: 60px;
    border-radius: 50%;
    display: flex;
    align-items: center;
    justify-content: center;
    font-weight: bold;
    color: white;
    box-shadow: var(--shadow-md);
    flex-shrink: 0;
    z-index: 1;
}

.time-0 {
    background: linear-gradient(135deg, #fa709a 0%, #fee140 100%);
}

.time-decision {
    background: linear-gradient(135deg, #667eea 0%, #764ba2 100%);
}

.time-120 {
    background: linear-gradient(135deg, #4facfe 0%, #00f2fe 100%);
}

.time-maladie-pluritronculaire {
    background: linear-gradient(135deg, #f093fb 0%, #f5576c 100%);
}

.timeline-content {
    flex: 1;
    background-color: var(--bg-secondary);
    padding: var(--spacing-lg);
    border-radius: var(--border-radius);
    border-left: 4px solid var(--primary-color);
}

.timeline-content h4 {
    font-size: var(--font-size-xl);
    color: var(--text-primary);
    margin-bottom: var(--spacing-md);
}

.treatment-box,
.procedure-box,
.mvd-box {
    background: white;
    padding: var(--spacing-lg);
    border-radius: var(--border-radius-sm);
    box-shadow: var(--shadow-sm);
    margin-top: var(--spacing-md);
}

.treatment-box.critical {
    border-left: 4px solid var(--danger-color);
}

.treatment-box h5,
.procedure-box h5,
.mvd-box h5 {
    color: var(--primary-color);
    margin-bottom: var(--spacing-md);
    display: flex;
    align-items: center;
    gap: var(--spacing-sm);
}

.treatment-box ul,
.procedure-box ul,
.mvd-box ul {
    list-style: none;
    padding-left: 0;
}

.treatment-box ul li,
.procedure-box ul li,
.mvd-box ul li {
    padding: var(--spacing-xs) 0;
    padding-left: var(--spacing-md);
    position: relative;
}

.treatment-box ul li::before,
.procedure-box ul li::before,
.mvd-box ul li::before {
    content: "•";
    color: var(--primary-color);
    font-weight: bold;
    position: absolute;
    left: 0;
}

.reperfusion-decision {
    display: grid;
    grid-template-columns: repeat(auto-fit, minmax(300px, 1fr));
    gap: var(--spacing-lg);
}

.reperfusion-option {
    background: white;
    padding: var(--spacing-lg);
    border-radius: var(--border-radius);
    box-shadow: var(--shadow-md);
    border: 2px solid transparent;
    transition: all 0.3s ease;
}

.reperfusion-option:hover {
    transform: translateY(-5px);
    box-shadow: var(--shadow-lg);
}

.reperfusion-option.preferred {
    border-color: var(--success-color);
    background: linear-gradient(to bottom, white, #f0fdf4);
}

.reperfusion-option.alternative {
    border-color: var(--warning-color);
    background: linear-gradient(to bottom, white, #fffbeb);
}

.option-header {
    display: flex;
    align-items: center;
    gap: var(--spacing-sm);
    margin-bottom: var(--spacing-md);
    padding-bottom: var(--spacing-sm);
    border-bottom: 2px solid var(--border-color);
}

.option-header i {
    font-size: 1.5rem;
    color: var(--primary-color);
}

.option-header h5 {
    font-size: var(--font-size-lg);
    color: var(--text-primary);
}

.option-content ul {
    list-style: none;
    padding: 0;
}

.option-content ul li {
    padding: var(--spacing-xs) 0;
    display: flex;
    align-items: center;
    gap: var(--spacing-sm);
}

.option-content ul li i {
    color: var(--primary-color);
}

.evidence-level {
    margin-top: var(--spacing-md);
    padding: var(--spacing-xs) var(--spacing-md);
    background-color: var(--primary-color);
    color: white;
    border-radius: 20px;
    display: inline-block;
    font-size: var(--font-size-sm);
    font-weight: 600;
}

.alert-box {
    margin-top: var(--spacing-md);
    padding: var(--spacing-md);
    background-color: #fef3c7;
    border-left: 4px solid var(--warning-color);
    border-radius: var(--border-radius-sm);
    display: flex;
    align-items: center;
    gap: var(--spacing-sm);
}

.alert-box i {
    color: var(--warning-color);
}

.mvd-strategy {
    display: flex;
    flex-direction: column;
    gap: var(--spacing-md);
}

.strategy-item {
    padding: var(--spacing-md);
    background-color: var(--bg-secondary);
    border-radius: var(--border-radius-sm);
    border-left: 3px solid var(--primary-color);
}

.strategy-item strong {
    display: block;
    color: var(--primary-color);
    margin-bottom: var(--spacing-xs);
}

/* ============================================
   NSTEMI Algorithm
   ============================================ */
.nstemi-algorithm {
    padding: var(--spacing-xl);
}

.troponin-algorithm {
    background: white;
    padding: var(--spacing-xl);
    border-radius: var(--border-radius);
    box-shadow: var(--shadow-md);
    margin-bottom: var(--spacing-xl);
}

.troponin-algorithm h4 {
    font-size: var(--font-size-2xl);
    color: var(--text-primary);
    margin-bottom: var(--spacing-lg);
    display: flex;
    align-items: center;
    gap: var(--spacing-sm);
}

.troponin-flow {
    display: flex;
    flex-direction: column;
    align-items: center;
    gap: var(--spacing-lg);
}

.troponin-step {
    width: 100%;
    max-width: 500px;
}

.step-box {
    background: linear-gradient(135deg, #667eea 0%, #764ba2 100%);
    color: white;
    padding: var(--spacing-lg);
    border-radius: var(--border-radius);
    text-align: center;
    box-shadow: var(--shadow-md);
}

.step-box h5 {
    font-size: var(--font-size-xl);
    margin-bottom: var(--spacing-sm);
}

.troponin-branches {
    display: grid;
    grid-template-columns: repeat(auto-fit, minmax(280px, 1fr));
    gap: var(--spacing-lg);
    width: 100%;
}

.branch-box {
    padding: var(--spacing-lg);
    border-radius: var(--border-radius);
    box-shadow: var(--shadow-md);
}

.branch-box.success {
    background: linear-gradient(to bottom, white, #f0fdf4);
    border: 2px solid var(--success-color);
}

.branch-box.danger {
    background: linear-gradient(to bottom, white, #fef2f2);
    border: 2px solid var(--danger-color);
}

.branch-box.warning {
    background: linear-gradient(to bottom, white, #fffbeb);
    border: 2px solid var(--warning-color);
}

.branch-box h5 {
    display: flex;
    align-items: center;
    gap: var(--spacing-sm);
    margin-bottom: var(--spacing-md);
    font-size: var(--font-size-lg);
}

.branch-box h5 i {
    font-size: 1.5rem;
}

.criteria {
    margin-bottom: var(--spacing-md);
}

.criteria strong {
    display: block;
    margin-bottom: var(--spacing-sm);
}

.criteria ul {
    list-style: none;
    padding: 0;
}

.criteria ul li {
    padding: var(--spacing-xs) 0;
    padding-left: var(--spacing-md);
    position: relative;
}

.criteria ul li::before {
    content: "▸";
    position: absolute;
    left: 0;
    font-weight: bold;
}

.decision-box {
    background-color: rgba(0, 0, 0, 0.05);
    padding: var(--spacing-md);
    border-radius: var(--border-radius-sm);
    display: flex;
    flex-direction: column;
    gap: var(--spacing-xs);
}

.decision-box i {
    font-size: 1.5rem;
    margin-bottom: var(--spacing-xs);
}

/* ============================================
   Risk Stratification
   ============================================ */
.risk-stratification {
    background: white;
    padding: var(--spacing-xl);
    border-radius: var(--border-radius);
    box-shadow: var(--shadow-md);
    margin-bottom: var(--spacing-xl);
}

.risk-stratification h4 {
    font-size: var(--font-size-2xl);
    color: var(--text-primary);
    margin-bottom: var(--spacing-lg);
    display: flex;
    align-items: center;
    gap: var(--spacing-sm);
}

.risk-categories {
    display: flex;
    flex-direction: column;
    gap: var(--spacing-lg);
}

.risk-category {
    border-radius: var(--border-radius);
    overflow: hidden;
    box-shadow: var(--shadow-md);
}

.category-header {
    padding: var(--spacing-lg);
    color: white;
    display: flex;
    align-items: center;
    gap: var(--spacing-md);
}

.risk-category.very-high .category-header {
    background: linear-gradient(135deg, #dc2626 0%, #991b1b 100%);
}

.risk-category.high .category-header {
    background: linear-gradient(135deg, #f59e0b 0%, #d97706 100%);
}

.risk-category.low .category-header {
    background: linear-gradient(135deg, #10b981 0%, #059669 100%);
}

.category-header i {
    font-size: 2rem;
}

.category-header h5 {
    font-size: var(--font-size-xl);
}

.category-content {
    padding: var(--spacing-lg);
    background: white;
}

.criteria-box {
    background-color: var(--bg-secondary);
    padding: var(--spacing-md);
    border-radius: var(--border-radius-sm);
    margin-bottom: var(--spacing-md);
}

.criteria-box strong {
    display: block;
    color: var(--text-primary);
    margin-bottom: var(--spacing-sm);
}

.criteria-box ul {
    list-style: none;
    padding: 0;
}

.criteria-box ul li {
    padding: var(--spacing-xs) 0;
    padding-left: var(--spacing-md);
    position: relative;
}

.criteria-box ul li::before {
    content: "✓";
    position: absolute;
    left: 0;
    color: var(--primary-color);
    font-weight: bold;
}

.strategy-box {
    padding: var(--spacing-lg);
    border-radius: var(--border-radius-sm);
    text-align: center;
}

.strategy-box.critical {
    background: linear-gradient(135deg, #fef2f2 0%, #fee2e2 100%);
    border: 2px solid var(--danger-color);
}

.strategy-box.high-risk {
    background: linear-gradient(135deg, #fffbeb 0%, #fef3c7 100%);
    border: 2px solid var(--warning-color);
}

.strategy-box.moderate-risk {
    background: linear-gradient(135deg, #f0fdf4 0%, #dcfce7 100%);
    border: 2px solid var(--success-color);
}

.strategy-box strong {
    display: flex;
    align-items: center;
    justify-content: center;
    gap: var(--spacing-sm);
    font-size: var(--font-size-lg);
    margin-bottom: var(--spacing-sm);
}

.strategy-box p.evidence {
    margin-top: var(--spacing-sm);
    font-weight: 600;
    color: var(--primary-color);
}

/* ============================================
   Antithrombotic Treatment
   ============================================ */
.antithrombotic-treatment {
    background: white;
    padding: var(--spacing-xl);
    border-radius: var(--border-radius);
    box-shadow: var(--shadow-md);
    margin-bottom: var(--spacing-xl);
}

.antithrombotic-treatment h4 {
    font-size: var(--font-size-2xl);
    color: var(--text-primary);
    margin-bottom: var(--spacing-lg);
    display: flex;
    align-items: center;
    gap: var(--spacing-sm);
}

.treatment-grid {
    display: grid;
    grid-template-columns: repeat(auto-fit, minmax(350px, 1fr));
    gap: var(--spacing-lg);
}

.treatment-card {
    border-radius: var(--border-radius);
    overflow: hidden;
    box-shadow: var(--shadow-md);
}

.card-header {
    padding: var(--spacing-lg);
    color: white;
}

.card-header.antiplatelet {
    background: linear-gradient(135deg, #667eea 0%, #764ba2 100%);
}

.card-header.anticoagulant {
    background: linear-gradient(135deg, #f093fb 0%, #f5576c 100%);
}

.card-header h5 {
    font-size: var(--font-size-xl);
    display: flex;
    align-items: center;
    gap: var(--spacing-sm);
}

.card-body {
    padding: var(--spacing-lg);
    background: white;
}

.drug-item {
    margin-bottom: var(--spacing-lg);
    padding-bottom: var(--spacing-lg);
    border-bottom: 1px solid var(--border-color);
}

.drug-item:last-child {
    border-bottom: none;
    margin-bottom: 0;
    padding-bottom: 0;
}

.drug-item strong {
    display: block;
    color: var(--text-primary);
    margin-bottom: var(--spacing-sm);
}

.drug-options {
    display: flex;
    flex-direction: column;
    gap: var(--spacing-sm);
    margin-top: var(--spacing-sm);
}

.option {
    padding: var(--spacing-md);
    border-radius: var(--border-radius-sm);
    display: flex;
    flex-direction: column;
    gap: var(--spacing-xs);
}

.option.preferred-drug {
    background: linear-gradient(to right, #f0fdf4, white);
    border-left: 3px solid var(--success-color);
}

.option.alternative-drug {
    background: linear-gradient(to right, #fef3c7, white);
    border-left: 3px solid var(--warning-color);
}

.drug-name {
    font-weight: 600;
    color: var(--text-primary);
}

.drug-dose {
    color: var(--text-secondary);
    font-size: var(--font-size-sm);
}

.drug-note {
    font-size: var(--font-size-xs);
    color: var(--text-light);
    font-style: italic;
}

.timing-note {
    margin-top: var(--spacing-md);
    padding: var(--spacing-md);
    background-color: #dbeafe;
    border-left: 3px solid var(--info-color);
    border-radius: var(--border-radius-sm);
    display: flex;
    align-items: start;
    gap: var(--spacing-sm);
}

.timing-note i {
    color: var(--info-color);
    margin-top: 2px;
}

.separator {
    text-align: center;
    font-weight: 600;
    color: var(--text-secondary);
    margin: var(--spacing-md) 0;
}

.drug-advantage {
    margin-top: var(--spacing-sm);
    color: var(--success-color);
    font-size: var(--font-size-sm);
    display: flex;
    align-items: center;
    gap: var(--spacing-xs);
}

.drug-use {
    margin-top: var(--spacing-sm);
    font-size: var(--font-size-sm);
    color: var(--text-secondary);
    font-style: italic;
}

/* ============================================
   Complications Section
   ============================================ */
.complications-section {
    background: white;
    padding: var(--spacing-xl);
    border-radius: var(--border-radius);
    box-shadow: var(--shadow-md);
    margin-top: var(--spacing-xl);
}

.complications-section h3 {
    font-size: var(--font-size-2xl);
    color: var(--text-primary);
    margin-bottom: var(--spacing-lg);
    display: flex;
    align-items: center;
    gap: var(--spacing-sm);
}

.complications-grid {
    display: grid;
    grid-template-columns: repeat(auto-fit, minmax(280px, 1fr));
    gap: var(--spacing-lg);
}

.complication-card {
    padding: var(--spacing-lg);
    border-radius: var(--border-radius);
    box-shadow: var(--shadow-md);
    transition: transform 0.3s ease;
}

.complication-card:hover {
    transform: translateY(-5px);
}

.complication-card.emergency {
    background: linear-gradient(to bottom, #fef2f2, white);
    border-left: 4px solid var(--danger-color);
}

.complication-card.warning {
    background: linear-gradient(to bottom, #fffbeb, white);
    border-left: 4px solid var(--warning-color);
}

.complication-card.severe {
    background: linear-gradient(to bottom, #fef3c7, white);
    border-left: 4px solid #f59e0b;
}

.complication-card.moderate {
    background: linear-gradient(to bottom, #f0fdf4, white);
    border-left: 4px solid var(--info-color);
}

.comp-icon {
    width: 60px;
    height: 60px;
    border-radius: 50%;
    display: flex;
    align-items: center;
    justify-content: center;
    margin-bottom: var(--spacing-md);
    font-size: 1.5rem;
    color: white;
}

.complication-card.emergency .comp-icon {
    background: var(--danger-color);
}

.complication-card.warning .comp-icon {
    background: var(--warning-color);
}

.complication-card.severe .comp-icon {
    background: #f59e0b;
}

.complication-card.moderate .comp-icon {
    background: var(--info-color);
}

.complication-card h4 {
    font-size: var(--font-size-lg);
    color: var(--text-primary);
    margin-bottom: var(--spacing-md);
}

.complication-card ul {
    list-style: none;
    padding: 0;
}

.complication-card ul li {
    padding: var(--spacing-xs) 0;
    padding-left: var(--spacing-md);
    position: relative;
    color: var(--text-secondary);
}

.complication-card ul li::before {
    content: "→";
    position: absolute;
    left: 0;
    color: var(--primary-color);
    font-weight: bold;
}

/* ============================================
   Rehabilitation Section
   ============================================ */
.readaptation-intro {
    margin-bottom: var(--spacing-xl);
}

.info-box {
    padding: var(--spacing-lg);
    border-radius: var(--border-radius);
    display: flex;
    align-items: start;
    gap: var(--spacing-md);
    box-shadow: var(--shadow-md);
}

.info-box.highlight {
    background: linear-gradient(135deg, #667eea 0%, #764ba2 100%);
    color: white;
}

.info-box i {
    font-size: 2rem;
    flex-shrink: 0;
}

.info-box strong {
    display: block;
    font-size: var(--font-size-lg);
    margin-bottom: var(--spacing-sm);
}

.evidence-badge {
    display: inline-block;
    padding: var(--spacing-xs) var(--spacing-md);
    background-color: rgba(255, 255, 255, 0.2);
    border-radius: 20px;
    font-size: var(--font-size-sm);
    font-weight: 600;
    margin-top: var(--spacing-sm);
}

.readaptation-phases {
    background: white;
    padding: var(--spacing-xl);
    border-radius: var(--border-radius);
    box-shadow: var(--shadow-md);
    margin-bottom: var(--spacing-xl);
}

.readaptation-phases h3 {
    font-size: var(--font-size-2xl);
    color: var(--text-primary);
    margin-bottom: var(--spacing-lg);
    display: flex;
    align-items: center;
    gap: var(--spacing-sm);
}

.phases-timeline {
    display: flex;
    flex-direction: column;
    gap: var(--spacing-xl);
}

.phase-item {
    display: flex;
    gap: var(--spacing-lg);
    position: relative;
}

.phase-item::before {
    content: '';
    position: absolute;
    left: 30px;
    top: 60px;
    bottom: -40px;
    width: 3px;
    background: linear-gradient(to bottom, var(--primary-color), var(--primary-light));
}

.phase-item:last-child::before {
    display: none;
}

.phase-marker {
    width: 60px;
    height: 60px;
    border-radius: 50%;
    display: flex;
    align-items: center;
    justify-content: center;
    font-weight: bold;
    font-size: var(--font-size-2xl);
    color: white;
    box-shadow: var(--shadow-md);
    flex-shrink: 0;
    z-index: 1;
}

.phase-1 .phase-marker {
    background: linear-gradient(135deg, #667eea 0%, #764ba2 100%);
}

.phase-2 .phase-marker {
    background: linear-gradient(135deg, #4facfe 0%, #00f2fe 100%);
}

.phase-3 .phase-marker {
    background: linear-gradient(135deg, #f093fb 0%, #f5576c 100%);
}

.phase-content {
    flex: 1;
}

.phase-content h4 {
    font-size: var(--font-size-xl);
    color: var(--text-primary);
    margin-bottom: var(--spacing-md);
    display: flex;
    align-items: center;
    gap: var(--spacing-sm);
}

.phase-details {
    background-color: var(--bg-secondary);
    padding: var(--spacing-lg);
    border-radius: var(--border-radius-sm);
    border-left: 4px solid var(--primary-color);
}

.phase-timing,
.phase-duration {
    font-size: var(--font-size-sm);
    color: var(--text-secondary);
    margin-bottom: var(--spacing-md);
}

.phase-objectives,
.phase-activities,
.phase-components {
    margin-bottom: var(--spacing-md);
}

.phase-objectives strong,
.phase-activities strong,
.phase-components h5 {
    display: block;
    color: var(--primary-color);
    margin-bottom: var(--spacing-sm);
}

.phase-objectives ul,
.phase-activities ul {
    list-style: none;
    padding: 0;
}

.phase-objectives ul li,
.phase-activities ul li {
    padding: var(--spacing-xs) 0;
    padding-left: var(--spacing-md);
    position: relative;
}

.phase-objectives ul li::before,
.phase-activities ul li::before {
    content: "▸";
    position: absolute;
    left: 0;
    color: var(--primary-color);
    font-weight: bold;
}

.phase-modalities {
    display: grid;
    grid-template-columns: repeat(auto-fit, minmax(250px, 1fr));
    gap: var(--spacing-md);
    margin-top: var(--spacing-md);
}

.modality {
    padding: var(--spacing-md);
    background: white;
    border-radius: var(--border-radius-sm);
    box-shadow: var(--shadow-sm);
}

.modality h5 {
    display: flex;
    align-items: center;
    gap: var(--spacing-sm);
    color: var(--text-primary);
    margin-bottom: var(--spacing-sm);
}

.components-grid {
    display: grid;
    grid-template-columns: repeat(auto-fit, minmax(200px, 1fr));
    gap: var(--spacing-md);
    margin-top: var(--spacing-md);
}

.component {
    padding: var(--spacing-md);
    background: white;
    border-radius: var(--border-radius-sm);
    box-shadow: var(--shadow-sm);
    text-align: center;
    transition: transform 0.3s ease;
}

.component:hover {
    transform: translateY(-3px);
    box-shadow: var(--shadow-md);
}

.component i {
    font-size: 2rem;
    color: var(--primary-color);
    margin-bottom: var(--spacing-sm);
}

.component strong {
    display: block;
    color: var(--text-primary);
    margin-bottom: var(--spacing-xs);
}

.component p {
    font-size: var(--font-size-sm);
    color: var(--text-secondary);
}

.exercise-protocol {
    margin-top: var(--spacing-lg);
    padding: var(--spacing-lg);
    background: white;
    border-radius: var(--border-radius-sm);
    box-shadow: var(--shadow-sm);
}

.exercise-protocol h5 {
    color: var(--primary-color);
    margin-bottom: var(--spacing-md);
    display: flex;
    align-items: center;
    gap: var(--spacing-sm);
}

.exercise-details {
    display: grid;
    grid-template-columns: repeat(auto-fit, minmax(300px, 1fr));
    gap: var(--spacing-lg);
}

.exercise-type {
    padding: var(--spacing-md);
    background-color: var(--bg-secondary);
    border-radius: var(--border-radius-sm);
    border-left: 3px solid var(--primary-color);
}

.exercise-type strong {
    display: block;
    color: var(--text-primary);
    margin-bottom: var(--spacing-sm);
}

/* Digital Rehabilitation */
.digital-rehabilitation {
    background: white;
    padding: var(--spacing-xl);
    border-radius: var(--border-radius);
    box-shadow: var(--shadow-md);
    margin-bottom: var(--spacing-xl);
}

.digital-rehabilitation h3 {
    font-size: var(--font-size-2xl);
    color: var(--text-primary);
    margin-bottom: var(--spacing-lg);
    display: flex;
    align-items: center;
    gap: var(--spacing-sm);
}

.digital-content {
    display: grid;
    grid-template-columns: repeat(auto-fit, minmax(350px, 1fr));
    gap: var(--spacing-lg);
}

.digital-benefits,
.digital-tools {
    padding: var(--spacing-lg);
    background-color: var(--bg-secondary);
    border-radius: var(--border-radius-sm);
    border-left: 4px solid var(--primary-color);
}

.digital-benefits h4,
.digital-tools h4 {
    color: var(--primary-color);
    margin-bottom: var(--spacing-md);
}

.digital-benefits ul li,
.digital-tools ul li {
    padding: var(--spacing-xs) 0;
    display: flex;
    align-items: center;
    gap: var(--spacing-sm);
}

.digital-benefits ul li i {
    color: var(--success-color);
}

/* Special Populations */
.special-populations {
    background: white;
    padding: var(--spacing-xl);
    border-radius: var(--border-radius);
    box-shadow: var(--shadow-md);
    margin-bottom: var(--spacing-xl);
}

.special-populations h3 {
    font-size: var(--font-size-2xl);
    color: var(--text-primary);
    margin-bottom: var(--spacing-lg);
    display: flex;
    align-items: center;
    gap: var(--spacing-sm);
}

.populations-grid {
    display: grid;
    grid-template-columns: repeat(auto-fit, minmax(280px, 1fr));
    gap: var(--spacing-lg);
}

.population-card {
    padding: var(--spacing-lg);
    background-color: var(--bg-secondary);
    border-radius: var(--border-radius);
    box-shadow: var(--shadow-sm);
    transition: transform 0.3s ease;
}

.population-card:hover {
    transform: translateY(-5px);
    box-shadow: var(--shadow-md);
}

.pop-icon {
    width: 60px;
    height: 60px;
    border-radius: 50%;
    background: linear-gradient(135deg, var(--primary-color), var(--primary-dark));
    color: white;
    display: flex;
    align-items: center;
    justify-content: center;
    font-size: 1.5rem;
    margin-bottom: var(--spacing-md);
}

.population-card h4 {
    font-size: var(--font-size-lg);
    color: var(--text-primary);
    margin-bottom: var(--spacing-md);
}

/* ============================================
   Prevention Section - Long-term Treatment
   ============================================ */
.longterm-antithrombotic {
    background: white;
    padding: var(--spacing-xl);
    border-radius: var(--border-radius);
    box-shadow: var(--shadow-md);
    margin-bottom: var(--spacing-xl);
}

.longterm-antithrombotic h3 {
    font-size: var(--font-size-2xl);
    color: var(--text-primary);
    margin-bottom: var(--spacing-lg);
    display: flex;
    align-items: center;
    gap: var(--spacing-sm);
}

.antithrombotic-timeline {
    display: flex;
    flex-direction: column;
    gap: var(--spacing-xl);
}

.timeline-period {
    border-radius: var(--border-radius);
    overflow: hidden;
    box-shadow: var(--shadow-md);
}

.period-header {
    padding: var(--spacing-lg);
    color: white;
    display: flex;
    justify-content: space-between;
    align-items: center;
}

.timeline-period.standard .period-header {
    background: linear-gradient(135deg, #667eea 0%, #764ba2 100%);
}

.timeline-period.longterm .period-header {
    background: linear-gradient(135deg, #4facfe 0%, #00f2fe 100%);
}

.period-header h4 {
    font-size: var(--font-size-xl);
    display: flex;
    align-items: center;
    gap: var(--spacing-sm);
}

.period-content {
    padding: var(--spacing-xl);
    background: white;
}

.treatment-regimen {
    margin-bottom: var(--spacing-lg);
}

.treatment-regimen h5 {
    color: var(--primary-color);
    margin-bottom: var(--spacing-md);
}

.drug-combination {
    display: flex;
    align-items: center;
    justify-content: center;
    gap: var(--spacing-lg);
    flex-wrap: wrap;
    padding: var(--spacing-lg);
    background-color: var(--bg-secondary);
    border-radius: var(--border-radius-sm);
}

.drug-item.primary {
    flex: 1;
    min-width: 200px;
    padding: var(--spacing-lg);
    background: white;
    border-radius: var(--border-radius-sm);
    box-shadow: var(--shadow-sm);
    display: flex;
    align-items: center;
    gap: var(--spacing-md);
}

.drug-item.primary i {
    font-size: 2rem;
    color: var(--primary-color);
}

.drug-item.primary.centered {
    justify-content: center;
    max-width: 400px;
    margin: 0 auto;
}

.plus-sign {
    font-size: var(--font-size-2xl);
    font-weight: bold;
    color: var(--primary-color);
}

.duration-note {
    margin-top: var(--spacing-md);
    padding: var(--spacing-md);
    background-color: #dbeafe;
    border-left: 3px solid var(--info-color);
    border-radius: var(--border-radius-sm);
    display: flex;
    align-items: center;
    gap: var(--spacing-sm);
}

.alternative-mono {
    margin-top: var(--spacing-md);
    padding: var(--spacing-md);
    background-color: #fef3c7;
    border-left: 3px solid var(--warning-color);
    border-radius: var(--border-radius-sm);
    display: flex;
    align-items: center;
    gap: var(--spacing-sm);
}

.alternative-strategies {
    margin-top: var(--spacing-xl);
}

.alternative-strategies h5 {
    color: var(--text-primary);
    margin-bottom: var(--spacing-md);
    display: flex;
    align-items: center;
    gap: var(--spacing-sm);
}

.strategy-options {
    display: flex;
    flex-direction: column;
    gap: var(--spacing-md);
}

.strategy-option {
    padding: var(--spacing-md);
    background-color: var(--bg-secondary);
    border-radius: var(--border-radius-sm);
    border-left: 3px solid var(--primary-color);
}

.strategy-label {
    display: flex;
    align-items: center;
    gap: var(--spacing-sm);
    margin-bottom: var(--spacing-sm);
}

.strategy-label strong {
    color: var(--text-primary);
}

.strategy-label .evidence {
    margin-left: auto;
    padding: 2px 8px;
    background-color: var(--primary-color);
    color: white;
    border-radius: 12px;
    font-size: var(--font-size-xs);
}

.strategy-detail {
    font-size: var(--font-size-sm);
    color: var(--text-secondary);
    font-style: italic;
    margin-top: var(--spacing-xs);
}

.dapt-prolongation {
    margin-top: var(--spacing-xl);
    padding: var(--spacing-lg);
    background-color: var(--bg-secondary);
    border-radius: var(--border-radius-sm);
    border: 2px dashed var(--primary-color);
}

.dapt-prolongation h5 {
    color: var(--text-primary);
    margin-bottom: var(--spacing-md);
    display: flex;
    align-items: center;
    gap: var(--spacing-sm);
}

.indication-intro {
    margin-bottom: var(--spacing-md);
    color: var(--text-secondary);
}

.prolongation-criteria {
    display: grid;
    grid-template-columns: 2fr 1fr;
    gap: var(--spacing-lg);
}

.criteria-result {
    display: flex;
    flex-direction: column;
    align-items: center;
    justify-content: center;
    gap: var(--spacing-md);
    padding: var(--spacing-lg);
    background: white;
    border-radius: var(--border-radius-sm);
    box-shadow: var(--shadow-sm);
}

.criteria-result i {
    font-size: 2rem;
    color: var(--primary-color);
}

/* Anticoagulation Section */
.anticoagulation-section {
    margin-top: var(--spacing-xl);
    padding: var(--spacing-xl);
    background-color: #fef3c7;
    border-radius: var(--border-radius);
    border: 2px solid var(--warning-color);
}

.anticoagulation-section h4 {
    color: var(--text-primary);
    margin-bottom: var(--spacing-lg);
    display: flex;
    align-items: center;
    gap: var(--spacing-sm);
}

.anticoag-timeline {
    display: flex;
    align-items: center;
    gap: var(--spacing-md);
    flex-wrap: wrap;
    justify-content: center;
}

.anticoag-period {
    flex: 1;
    min-width: 200px;
    padding: var(--spacing-lg);
    background: white;
    border-radius: var(--border-radius-sm);
    box-shadow: var(--shadow-sm);
}

.period-label {
    display: flex;
    align-items: center;
    gap: var(--spacing-sm);
    margin-bottom: var(--spacing-md);
    font-weight: 600;
    color: var(--text-primary);
}

.period-label i {
    color: var(--warning-color);
}

.regimen {
    text-align: center;
}

.regimen p:first-child {
    font-weight: 600;
    color: var(--text-primary);
    margin-bottom: var(--spacing-xs);
}

.regimen .evidence {
    display: inline-block;
    margin-top: var(--spacing-sm);
    padding: 2px 8px;
    background-color: var(--success-color);
    color: white;
    border-radius: 12px;
    font-size: var(--font-size-xs);
}

.anticoag-arrow {
    font-size: 1.5rem;
    color: var(--warning-color);
}

.anticoag-note {
    margin-top: var(--spacing-lg);
    padding: var(--spacing-md);
    background: white;
    border-radius: var(--border-radius-sm);
    display: flex;
    align-items: start;
    gap: var(--spacing-sm);
}

.anticoag-note i {
    color: var(--info-color);
    margin-top: 2px;
}

/* Lipid Management */
.lipid-management {
    background: white;
    padding: var(--spacing-xl);
    border-radius: var(--border-radius);
    box-shadow: var(--shadow-md);
    margin-bottom: var(--spacing-xl);
}

.lipid-management h3 {
    font-size: var(--font-size-2xl);
    color: var(--text-primary);
    margin-bottom: var(--spacing-lg);
    display: flex;
    align-items: center;
    gap: var(--spacing-sm);
}

.lipid-targets {
    display: grid;
    grid-template-columns: repeat(auto-fit, minmax(350px, 1fr));
    gap: var(--spacing-lg);
    margin-bottom: var(--spacing-xl);
}

.target-box {
    border-radius: var(--border-radius);
    overflow: hidden;
    box-shadow: var(--shadow-md);
}

.target-header {
    padding: var(--spacing-lg);
    color: white;
    display: flex;
    align-items: center;
    gap: var(--spacing-md);
}

.target-box.primary-target .target-header {
    background: linear-gradient(135deg, #10b981 0%, #059669 100%);
}

.target-box.secondary-target .target-header {
    background: linear-gradient(135deg, #f59e0b 0%, #d97706 100%);
}

.target-header i {
    font-size: 2rem;
}

.target-header h4 {
    font-size: var(--font-size-xl);
}

.target-values {
    padding: var(--spacing-xl);
    background: white;
    display: flex;
    align-items: center;
    justify-content: center;
    gap: var(--spacing-lg);
    flex-wrap: wrap;
}

.value-item {
    text-align: center;
}

.value-item.main-value .value-number {
    font-size: var(--font-size-4xl);
    font-weight: 700;
    color: var(--primary-color);
}

.value-item .value-number {
    font-size: var(--font-size-3xl);
    font-weight: 700;
    color: var(--text-primary);
}

.value-detail {
    font-size: var(--font-size-sm);
    color: var(--text-secondary);
    margin-top: var(--spacing-xs);
}

.value-plus {
    font-size: var(--font-size-2xl);
    font-weight: bold;
    color: var(--primary-color);
}

.target-note {
    padding: var(--spacing-md);
    background-color: var(--bg-secondary);
    display: flex;
    flex-direction: column;
    align-items: center;
    gap: var(--spacing-xs);
}

.target-note i {
    color: var(--info-color);
}

/* Lipid Algorithm */
.lipid-algorithm {
    margin-top: var(--spacing-xl);
}

.lipid-algorithm h4 {
    font-size: var(--font-size-2xl);
    color: var(--text-primary);
    margin-bottom: var(--spacing-lg);
    display: flex;
    align-items: center;
    gap: var(--spacing-sm);
}

.algorithm-steps {
    display: flex;
    flex-direction: column;
    align-items: center;
    gap: var(--spacing-md);
}

.algo-step {
    width: 100%;
    max-width: 800px;
    display: flex;
    gap: var(--spacing-lg);
    align-items: stretch;
}

.step-number {
    width: 60px;
    height: 60px;
    border-radius: 50%;
    background: linear-gradient(135deg, var(--primary-color), var(--primary-dark));
    color: white;
    display: flex;
    align-items: center;
    justify-content: center;
    font-size: var(--font-size-2xl);
    font-weight: bold;
    flex-shrink: 0;
    box-shadow: var(--shadow-md);
}

.step-content {
    flex: 1;
    padding: var(--spacing-lg);
    background-color: var(--bg-secondary);
    border-radius: var(--border-radius-sm);
    border-left: 4px solid var(--primary-color);
}

.step-content h5 {
    color: var(--text-primary);
    margin-bottom: var(--spacing-md);
}

.drug-box.pcsk9 {
    background: linear-gradient(to bottom, #f0fdf4, white);
    border: 2px solid var(--success-color);
}

.algo-arrow {
    font-size: 2rem;
    color: var(--primary-color);
    text-align: center;
}

.evaluation-box {
    background: white;
    padding: var(--spacing-md);
    border-radius: var(--border-radius-sm);
    box-shadow: var(--shadow-sm);
}

.decision-branch {
    display: grid;
    grid-template-columns: repeat(auto-fit, minmax(200px, 1fr));
    gap: var(--spacing-md);
    margin-top: var(--spacing-md);
}

.branch {
    padding: var(--spacing-md);
    border-radius: var(--border-radius-sm);
    text-align: center;
}

.branch.success {
    background: linear-gradient(to bottom, #f0fdf4, white);
    border: 2px solid var(--success-color);
}

.branch.warning {
    background: linear-gradient(to bottom, #fffbeb, white);
    border: 2px solid var(--warning-color);
}

.branch i {
    font-size: 1.5rem;
    margin-bottom: var(--spacing-xs);
}

.branch.success i {
    color: var(--success-color);
}

.branch.warning i {
    color: var(--warning-color);
}

.triglycerides-section {
    margin-top: var(--spacing-xl);
    padding: var(--spacing-lg);
    background-color: #eff6ff;
    border-radius: var(--border-radius-sm);
    border-left: 4px solid var(--info-color);
}

.triglycerides-section h5 {
    color: var(--text-primary);
    margin-bottom: var(--spacing-md);
    display: flex;
    align-items: center;
    gap: var(--spacing-sm);
}

.tg-management {
    padding: var(--spacing-md);
    background: white;
    border-radius: var(--border-radius-sm);
}

/* Beta-Blockers Section */
.beta-blockers-section {
    background: white;
    padding: var(--spacing-xl);
    border-radius: var(--border-radius);
    box-shadow: var(--shadow-md);
    margin-bottom: var(--spacing-xl);
}

.beta-blockers-section h3 {
    font-size: var(--font-size-2xl);
    color: var(--text-primary);
    margin-bottom: var(--spacing-lg);
    display: flex;
    align-items: center;
    gap: var(--spacing-sm);
}

.bb-indications {
    display: flex;
    flex-direction: column;
    gap: var(--spacing-lg);
}

.indication-box {
    border-radius: var(--border-radius);
    overflow: hidden;
    box-shadow: var(--shadow-md);
}

.indication-header {
    padding: var(--spacing-lg);
    color: white;
    display: flex;
    align-items: center;
    gap: var(--spacing-md);
}

.indication-box.mandatory .indication-header {
    background: linear-gradient(135deg, #dc2626 0%, #991b1b 100%);
}

.indication-box.consider .indication-header {
    background: linear-gradient(135deg, #4facfe 0%, #00f2fe 100%);
}

.indication-header i {
    font-size: 2rem;
}

.indication-header h4 {
    font-size: var(--font-size-xl);
}

.indication-content {
    padding: var(--spacing-xl);
    background: white;
}

.patient-criteria {
    padding: var(--spacing-md);
    background-color: var(--bg-secondary);
    border-radius: var(--border-radius-sm);
    margin-bottom: var(--spacing-md);
}

.patient-criteria strong {
    display: block;
    color: var(--primary-color);
    margin-bottom: var(--spacing-xs);
}

.drugs-list h5,
.benefits h5,
.ongoing-trials p:first-child,
.current-practice p:first-child {
    color: var(--text-primary);
    font-weight: 600;
    margin-bottom: var(--spacing-sm);
}

.benefits {
    margin-top: var(--spacing-md);
    padding: var(--spacing-md);
    background: linear-gradient(to bottom, #f0fdf4, white);
    border-radius: var(--border-radius-sm);
    border-left: 3px solid var(--success-color);
}

.benefits i {
    color: var(--success-color);
    margin-right: var(--spacing-xs);
}

.ongoing-trials {
    margin-top: var(--spacing-md);
    padding: var(--spacing-md);
    background-color: #eff6ff;
    border-radius: var(--border-radius-sm);
    border-left: 3px solid var(--info-color);
}

.ongoing-trials i {
    color: var(--info-color);
    margin-right: var(--spacing-xs);
}

.bb-titration {
    margin-top: var(--spacing-xl);
    padding: var(--spacing-lg);
    background-color: var(--bg-secondary);
    border-radius: var(--border-radius-sm);
}

.bb-titration h4 {
    color: var(--text-primary);
    margin-bottom: var(--spacing-md);
    display: flex;
    align-items: center;
    gap: var(--spacing-sm);
}

.titration-content {
    display: grid;
    grid-template-columns: repeat(auto-fit, minmax(300px, 1fr));
    gap: var(--spacing-lg);
}

.titration-steps,
.contraindications {
    padding: var(--spacing-md);
    background: white;
    border-radius: var(--border-radius-sm);
    box-shadow: var(--shadow-sm);
}

.titration-rule {
    padding: var(--spacing-sm) 0;
    display: flex;
    align-items: start;
    gap: var(--spacing-sm);
}

.titration-rule i {
    color: var(--primary-color);
    margin-top: 2px;
}

.contraindications h5 {
    color: var(--danger-color);
    margin-bottom: var(--spacing-md);
}

/* RAAS Inhibitors */
.raas-inhibitors {
    background: white;
    padding: var(--spacing-xl);
    border-radius: var(--border-radius);
    box-shadow: var(--shadow-md);
    margin-bottom: var(--spacing-xl);
}

.raas-inhibitors h3 {
    font-size: var(--font-size-2xl);
    color: var(--text-primary);
    margin-bottom: var(--spacing-lg);
    display: flex;
    align-items: center;
    gap: var(--spacing-sm);
}

.raas-grid {
    display: grid;
    grid-template-columns: repeat(auto-fit, minmax(300px, 1fr));
    gap: var(--spacing-lg);
}

.raas-card {
    border-radius: var(--border-radius);
    overflow: hidden;
    box-shadow: var(--shadow-md);
}

.raas-card .card-header {
    padding: var(--spacing-lg);
    background: linear-gradient(135deg, #667eea 0%, #764ba2 100%);
    color: white;
}

.raas-card .card-header h4 {
    font-size: var(--font-size-xl);
    display: flex;
    align-items: center;
    gap: var(--spacing-sm);
}

.raas-card .card-content {
    padding: var(--spacing-lg);
    background: white;
}

.indication-box.strong {
    background: linear-gradient(to bottom, #fef2f2, white);
    border-left: 3px solid var(--danger-color);
}

.indication-box.moderate {
    background: linear-gradient(to bottom, #eff6ff, white);
    border-left: 3px solid var(--info-color);
}

.dosing,
.benefit,
.monitoring {
    margin-top: var(--spacing-md);
}

.benefit {
    padding: var(--spacing-md);
    background: linear-gradient(to bottom, #f0fdf4, white);
    border-radius: var(--border-radius-sm);
    display: flex;
    align-items: start;
    gap: var(--spacing-sm);
}

.benefit i {
    color: var(--success-color);
    margin-top: 2px;
}

.monitoring {
    padding: var(--spacing-md);
    background-color: #fef3c7;
    border-radius: var(--border-radius-sm);
    border-left: 3px solid var(--warning-color);
}

.monitoring h5 {
    color: var(--text-primary);
    margin-bottom: var(--spacing-sm);
    display: flex;
    align-items: center;
    gap: var(--spacing-xs);
}

/* Diabetes Cardio Drugs */
.diabetes-cardio-drugs {
    background: white;
    padding: var(--spacing-xl);
    border-radius: var(--border-radius);
    box-shadow: var(--shadow-md);
    margin-bottom: var(--spacing-xl);
}

.diabetes-cardio-drugs h3 {
    font-size: var(--font-size-2xl);
    color: var(--text-primary);
    margin-bottom: var(--spacing-lg);
    display: flex;
    align-items: center;
    gap: var(--spacing-sm);
}

.diabetes-drugs-grid {
    display: grid;
    grid-template-columns: repeat(auto-fit, minmax(400px, 1fr));
    gap: var(--spacing-lg);
    margin-bottom: var(--spacing-xl);
}

.drug-class-card {
    border-radius: var(--border-radius);
    overflow: hidden;
    box-shadow: var(--shadow-lg);
}

.class-header {
    padding: var(--spacing-lg);
    color: white;
}

.drug-class-card.sglt2 .class-header {
    background: linear-gradient(135deg, #10b981 0%, #059669 100%);
}

.drug-class-card.glp1 .class-header {
    background: linear-gradient(135deg, #6366f1 0%, #4f46e5 100%);
}

.class-header h4 {
    font-size: var(--font-size-xl);
    display: flex;
    align-items: center;
    gap: var(--spacing-sm);
}

.class-content {
    padding: var(--spacing-xl);
    background: white;
}

.indication-strong {
    padding: var(--spacing-md);
    background-color: var(--bg-secondary);
    border-radius: var(--border-radius-sm);
    border-left: 3px solid var(--primary-color);
    margin-bottom: var(--spacing-md);
}

.molecules {
    margin-bottom: var(--spacing-md);
}

.benefits-box {
    padding: var(--spacing-md);
    background: linear-gradient(to bottom, #f0fdf4, white);
    border-radius: var(--border-radius-sm);
    border-left: 3px solid var(--success-color);
    margin-bottom: var(--spacing-md);
}

.monitoring-box,
.side-effects {
    padding: var(--spacing-md);
    background-color: #fef3c7;
    border-radius: var(--border-radius-sm);
    border-left: 3px solid var(--warning-color);
}

.diabetes-targets {
    padding: var(--spacing-lg);
    background-color: var(--bg-secondary);
    border-radius: var(--border-radius-sm);
}

.diabetes-targets h4 {
    color: var(--text-primary);
    margin-bottom: var(--spacing-md);
    display: flex;
    align-items: center;
    gap: var(--spacing-sm);
}

.targets-content {
    display: flex;
    flex-direction: column;
    gap: var(--spacing-md);
}

.target-item {
    padding: var(--spacing-md);
    background: white;
    border-radius: var(--border-radius-sm);
    box-shadow: var(--shadow-sm);
}

.target-value {
    font-size: var(--font-size-xl);
    font-weight: 700;
    color: var(--primary-color);
    display: block;
    margin: var(--spacing-xs) 0;
}

.target-note-box {
    margin-top: var(--spacing-md);
    padding: var(--spacing-md);
    background-color: #fef2f2;
    border-left: 3px solid var(--danger-color);
    border-radius: var(--border-radius-sm);
    display: flex;
    align-items: start;
    gap: var(--spacing-sm);
}

.target-note-box i {
    color: var(--danger-color);
    margin-top: 2px;
}

/* Polypill and Adherence */
.polypill-adherence {
    background: white;
    padding: var(--spacing-xl);
    border-radius: var(--border-radius);
    box-shadow: var(--shadow-md);
    margin-bottom: var(--spacing-xl);
}

.polypill-adherence h3 {
    font-size: var(--font-size-2xl);
    color: var(--text-primary);
    margin-bottom: var(--spacing-lg);
    display: flex;
    align-items: center;
    gap: var(--spacing-sm);
}

.polypill-section {
    padding: var(--spacing-lg);
    background-color: var(--bg-secondary);
    border-radius: var(--border-radius-sm);
    margin-bottom: var(--spacing-xl);
}

.polypill-intro {
    display: flex;
    align-items: start;
    gap: var(--spacing-lg);
    margin-bottom: var(--spacing-lg);
}

.intro-icon {
    width: 80px;
    height: 80px;
    border-radius: 50%;
    background: linear-gradient(135deg, var(--primary-color), var(--primary-dark));
    color: white;
    display: flex;
    align-items: center;
    justify-content: center;
    font-size: 2rem;
    flex-shrink: 0;
}

.intro-content {
    flex: 1;
}

.intro-content h4 {
    color: var(--text-primary);
    margin-bottom: var(--spacing-sm);
}

.polypill-composition {
    margin-bottom: var(--spacing-lg);
}

.polypill-composition h5 {
    color: var(--text-primary);
    margin-bottom: var(--spacing-md);
}

.composition-pills {
    display: flex;
    align-items: center;
    justify-content: center;
    gap: var(--spacing-md);
    flex-wrap: wrap;
    padding: var(--spacing-lg);
    background: white;
    border-radius: var(--border-radius-sm);
}

.pill-component {
    padding: var(--spacing-md);
    background: linear-gradient(135deg, #f0fdf4 0%, white 100%);
    border: 2px solid var(--success-color);
    border-radius: var(--border-radius-sm);
    text-align: center;
    min-width: 150px;
}

.pill-component i {
    font-size: 1.5rem;
    color: var(--primary-color);
    margin-bottom: var(--spacing-xs);
}

.pill-component strong {
    display: block;
    color: var(--text-primary);
    margin-bottom: var(--spacing-xs);
}

.pill-component span {
    font-size: var(--font-size-sm);
    color: var(--text-secondary);
}

.composition-pills .plus {
    font-size: var(--font-size-2xl);
    font-weight: bold;
    color: var(--success-color);
}

.polypill-benefits {
    margin-bottom: var(--spacing-lg);
}

.polypill-benefits h5 {
    color: var(--text-primary);
    margin-bottom: var(--spacing-md);
    display: flex;
    align-items: center;
    gap: var(--spacing-sm);
}

.polypill-benefits h5 i {
    color: var(--success-color);
}

.benefits-grid {
    display: grid;
    grid-template-columns: repeat(auto-fit, minmax(200px, 1fr));
    gap: var(--spacing-md);
}

.benefit-item {
    padding: var(--spacing-lg);
    background: white;
    border-radius: var(--border-radius-sm);
    text-align: center;
    box-shadow: var(--shadow-sm);
}

.benefit-value {
    font-size: var(--font-size-4xl);
    font-weight: 700;
    color: var(--success-color);
    margin-bottom: var(--spacing-xs);
}

.polypill-who {
    padding: var(--spacing-md);
    background: white;
    border-radius: var(--border-radius-sm);
}

.polypill-who h5 {
    color: var(--text-primary);
    margin-bottom: var(--spacing-md);
}

.adherence-strategies {
    margin-top: var(--spacing-xl);
}

.adherence-strategies h4 {
    color: var(--text-primary);
    margin-bottom: var(--spacing-lg);
    display: flex;
    align-items: center;
    gap: var(--spacing-sm);
}

.strategies-grid {
    display: grid;
    grid-template-columns: repeat(auto-fit, minmax(280px, 1fr));
    gap: var(--spacing-lg);
    margin-bottom: var(--spacing-lg);
}

.strategy-card {
    padding: var(--spacing-lg);
    background: white;
    border-radius: var(--border-radius);
    box-shadow: var(--shadow-md);
    transition: transform 0.3s ease;
}

.strategy-card:hover {
    transform: translateY(-5px);
    box-shadow: var(--shadow-lg);
}

.strategy-icon {
    width: 60px;
    height: 60px;
    border-radius: 50%;
    background: linear-gradient(135deg, var(--primary-color), var(--primary-dark));
    color: white;
    display: flex;
    align-items: center;
    justify-content: center;
    font-size: 1.5rem;
    margin-bottom: var(--spacing-md);
}

.strategy-card h5 {
    color: var(--text-primary);
    margin-bottom: var(--spacing-md);
}

.adherence-measurement {
    padding: var(--spacing-lg);
    background-color: var(--bg-secondary);
    border-radius: var(--border-radius-sm);
}

.adherence-measurement h5 {
    color: var(--text-primary);
    margin-bottom: var(--spacing-md);
    display: flex;
    align-items: center;
    gap: var(--spacing-sm);
}

/* Other Prevention Measures */
.other-prevention {
    background: white;
    padding: var(--spacing-xl);
    border-radius: var(--border-radius);
    box-shadow: var(--shadow-md);
    margin-bottom: var(--spacing-xl);
}

.other-prevention h3 {
    font-size: var(--font-size-2xl);
    color: var(--text-primary);
    margin-bottom: var(--spacing-lg);
    display: flex;
    align-items: center;
    gap: var(--spacing-sm);
}

.other-measures-grid {
    display: grid;
    grid-template-columns: repeat(auto-fit, minmax(300px, 1fr));
    gap: var(--spacing-lg);
}

.measure-card {
    padding: var(--spacing-lg);
    border-radius: var(--border-radius);
    background-color: var(--bg-secondary);
    box-shadow: var(--shadow-sm);
    transition: transform 0.3s ease;
}

.measure-card:hover {
    transform: translateY(-3px);
    box-shadow: var(--shadow-md);
}

.measure-icon {
    width: 60px;
    height: 60px;
    border-radius: 50%;
    display: flex;
    align-items: center;
    justify-content: center;
    font-size: 1.5rem;
    color: white;
    margin-bottom: var(--spacing-md);
}

.measure-icon.pressure {
    background: linear-gradient(135deg, #3b82f6 0%, #1d4ed8 100%);
}

.measure-icon.vaccine {
    background: linear-gradient(135deg, #10b981 0%, #059669 100%);
}

.measure-icon.gastro {
    background: linear-gradient(135deg, #f59e0b 0%, #d97706 100%);
}

.measure-icon.lifestyle {
    background: linear-gradient(135deg, #f093fb 0%, #f5576c 100%);
}

.measure-card h4 {
    font-size: var(--font-size-lg);
    color: var(--text-primary);
    margin-bottom: var(--spacing-md);
}

.measure-target {
    margin-bottom: var(--spacing-md);
}

.measure-details {
    padding: var(--spacing-md);
    background: white;
    border-radius: var(--border-radius-sm);
}

.lifestyle-item {
    padding: var(--spacing-sm) 0;
    border-bottom: 1px solid var(--border-color);
}

.lifestyle-item:last-child {
    border-bottom: none;
}

.benefit-note {
    margin-top: var(--spacing-md);
    padding: var(--spacing-sm);
    background: linear-gradient(to bottom, #f0fdf4, white);
    border-radius: var(--border-radius-sm);
    display: flex;
    align-items: center;
    gap: var(--spacing-sm);
}

.benefit-note i {
    color: var(--success-color);
}

/* ============================================
   Follow-up Section
   ============================================ */
.followup-timeline {
    background: white;
    padding: var(--spacing-xl);
    border-radius: var(--border-radius);
    box-shadow: var(--shadow-md);
    margin-bottom: var(--spacing-xl);
}

.followup-timeline h3 {
    font-size: var(--font-size-2xl);
    color: var(--text-primary);
    margin-bottom: var(--spacing-lg);
    display: flex;
    align-items: center;
    gap: var(--spacing-sm);
}

.followup-schedule {
    display: flex;
    flex-direction: column;
    gap: var(--spacing-xl);
}

.followup-item {
    display: flex;
    gap: var(--spacing-lg);
}

.visit-marker {
    display: flex;
    flex-direction: column;
    align-items: center;
    gap: var(--spacing-sm);
    min-width: 120px;
}

.visit-marker i {
    font-size: 2rem;
    color: var(--primary-color);
}

.visit-timing {
    padding: var(--spacing-sm) var(--spacing-md);
    background-color: var(--primary-color);
    color: white;
    border-radius: 20px;
    font-weight: 600;
    font-size: var(--font-size-sm);
}

.visit-content {
    flex: 1;
    padding: var(--spacing-lg);
    background-color: var(--bg-secondary);
    border-radius: var(--border-radius-sm);
    border-left: 4px solid var(--primary-color);
}

.visit-content h4 {
    font-size: var(--font-size-xl);
    color: var(--text-primary);
    margin-bottom: var(--spacing-md);
}

.visit-objectives,
.visit-exams {
    margin-bottom: var(--spacing-md);
}

.visit-objectives h5,
.visit-exams h5 {
    color: var(--primary-color);
    margin-bottom: var(--spacing-sm);
    display: flex;
    align-items: center;
    gap: var(--spacing-sm);
}

/* Urgent Reassessment */
.urgent-reassessment {
    background: white;
    padding: var(--spacing-xl);
    border-radius: var(--border-radius);
    box-shadow: var(--shadow-md);
    margin-bottom: var(--spacing-xl);
}

.urgent-reassessment h3 {
    font-size: var(--font-size-2xl);
    color: var(--danger-color);
    margin-bottom: var(--spacing-lg);
    display: flex;
    align-items: center;
    gap: var(--spacing-sm);
}

.alert-signs {
    display: grid;
    grid-template-columns: repeat(auto-fit, minmax(280px, 1fr));
    gap: var(--spacing-lg);
}

.alert-card {
    padding: var(--spacing-lg);
    border-radius: var(--border-radius);
    box-shadow: var(--shadow-md);
}

.alert-card.critical {
    background: linear-gradient(to bottom, #fef2f2, white);
    border-left: 4px solid var(--danger-color);
}

.alert-card.severe {
    background: linear-gradient(to bottom, #fef3c7, white);
    border-left: 4px solid #f59e0b;
}

.alert-card.warning {
    background: linear-gradient(to bottom, #fffbeb, white);
    border-left: 4px solid var(--warning-color);
}

.alert-card.moderate {
    background: linear-gradient(to bottom, #eff6ff, white);
    border-left: 4px solid var(--info-color);
}

.alert-icon {
    width: 60px;
    height: 60px;
    border-radius: 50%;
    display: flex;
    align-items: center;
    justify-content: center;
    font-size: 1.5rem;
    color: white;
    margin-bottom: var(--spacing-md);
}

.alert-card.critical .alert-icon {
    background: var(--danger-color);
}

.alert-card.severe .alert-icon {
    background: #f59e0b;
}

.alert-card.warning .alert-icon {
    background: var(--warning-color);
}

.alert-card.moderate .alert-icon {
    background: var(--info-color);
}

.alert-card h4 {
    font-size: var(--font-size-lg);
    color: var(--text-primary);
    margin-bottom: var(--spacing-md);
}

.alert-card .action {
    margin-top: var(--spacing-md);
    padding: var(--spacing-sm);
    background-color: rgba(0, 0, 0, 0.05);
    border-radius: var(--border-radius-sm);
    font-size: var(--font-size-sm);
}

/* Therapeutic Targets Summary */
.therapeutic-targets-summary {
    background: white;
    padding: var(--spacing-xl);
    border-radius: var(--border-radius);
    box-shadow: var(--shadow-md);
    margin-bottom: var(--spacing-xl);
}

.therapeutic-targets-summary h3 {
    font-size: var(--font-size-2xl);
    color: var(--text-primary);
    margin-bottom: var(--spacing-lg);
    display: flex;
    align-items: center;
    gap: var(--spacing-sm);
}

.targets-table-container {
    overflow-x: auto;
}

.targets-table {
    width: 100%;
    border-collapse: collapse;
    background: white;
}

.targets-table thead {
    background: linear-gradient(135deg, #667eea 0%, #764ba2 100%);
    color: white;
}

.targets-table th,
.targets-table td {
    padding: var(--spacing-md);
    text-align: left;
    border-bottom: 1px solid var(--border-color);
}

.targets-table th {
    font-weight: 600;
    font-size: var(--font-size-sm);
    text-transform: uppercase;
}

.targets-table tbody tr:hover {
    background-color: var(--bg-secondary);
}

.targets-table td:first-child {
    font-weight: 500;
}

.class-badge {
    display: inline-block;
    padding: 4px 12px;
    border-radius: 12px;
    font-size: var(--font-size-xs);
    font-weight: 600;
    color: white;
}

.class-1 {
    background-color: var(--success-color);
}

.class-2a {
    background-color: var(--info-color);
}

/* Care Coordination */
.care-coordination {
    background: white;
    padding: var(--spacing-xl);
    border-radius: var(--border-radius);
    box-shadow: var(--shadow-md);
    margin-bottom: var(--spacing-xl);
}

.care-coordination h3 {
    font-size: var(--font-size-2xl);
    color: var(--text-primary);
    margin-bottom: var(--spacing-lg);
    display: flex;
    align-items: center;
    gap: var(--spacing-sm);
}

.coordination-team {
    display: grid;
    grid-template-columns: repeat(auto-fit, minmax(250px, 1fr));
    gap: var(--spacing-lg);
}

.team-member {
    padding: var(--spacing-lg);
    background-color: var(--bg-secondary);
    border-radius: var(--border-radius);
    text-align: center;
    transition: transform 0.3s ease;
}

.team-member:hover {
    transform: translateY(-5px);
    box-shadow: var(--shadow-md);
}

.member-icon {
    width: 60px;
    height: 60px;
    border-radius: 50%;
    background: linear-gradient(135deg, var(--primary-color), var(--primary-dark));
    color: white;
    display: flex;
    align-items: center;
    justify-content: center;
    font-size: 1.5rem;
    margin: 0 auto var(--spacing-md);
}

.team-member h4 {
    font-size: var(--font-size-lg);
    color: var(--text-primary);
    margin-bottom: var(--spacing-sm);
}

.team-member p {
    font-size: var(--font-size-sm);
    color: var(--text-secondary);
    line-height: 1.6;
}

/* ============================================
   Footer
   ============================================ */
.footer {
    background: linear-gradient(135deg, #667eea 0%, #764ba2 100%);
    color: white;
    padding: var(--spacing-xl) 0 var(--spacing-md);
    margin-top: var(--spacing-xl);
}

.footer-content {
    display: grid;
    grid-template-columns: repeat(auto-fit, minmax(250px, 1fr));
    gap: var(--spacing-lg);
    margin-bottom: var(--spacing-lg);
}

.footer-section h4 {
    font-size: var(--font-size-lg);
    margin-bottom: var(--spacing-md);
}

.footer-section p,
.footer-section ul {
    font-size: var(--font-size-sm);
    line-height: 1.8;
}

.footer-section ul {
    list-style: none;
    padding: 0;
}

.footer-section ul li {
    padding: var(--spacing-xs) 0;
}

.footer-bottom {
    text-align: center;
    padding-top: var(--spacing-md);
    border-top: 1px solid rgba(255, 255, 255, 0.2);
}

.footer-bottom p {
    font-size: var(--font-size-sm);
    opacity: 0.9;
}

/* ============================================
   Modal
   ============================================ */
.modal {
    display: none;
    position: fixed;
    z-index: 1000;
    left: 0;
    top: 0;
    width: 100%;
    height: 100%;
    background-color: rgba(0, 0, 0, 0.7);
    animation: fadeIn 0.3s ease;
}

.modal-content {
    background-color: white;
    margin: 5% auto;
    padding: var(--spacing-xl);
    border-radius: var(--border-radius);
    max-width: 800px;
    max-height: 80vh;
    overflow-y: auto;
    box-shadow: var(--shadow-xl);
    animation: slideDown 0.3s ease;
}

@keyframes slideDown {
    from {
        transform: translateY(-50px);
        opacity: 0;
    }
    to {
        transform: translateY(0);
        opacity: 1;
    }
}

.modal-close {
    color: var(--text-secondary);
    float: right;
    font-size: 2rem;
    font-weight: bold;
    cursor: pointer;
    transition: color 0.3s ease;
}

.modal-close:hover {
    color: var(--danger-color);
}

/* ============================================
   Responsive Design
   ============================================ */
@media screen and (max-width: 768px) {
    .header h1 {
        font-size: var(--font-size-3xl);
    }

    .nav-list {
        flex-direction: column;
        align-items: stretch;
    }

    .nav-link {
        justify-content: center;
    }

    .intro-grid,
    .definition-grid,
    .treatment-grid,
    .complications-grid,
    .readaptation-phases,
    .populations-grid,
    .lipid-targets,
    .diabetes-drugs-grid,
    .strategies-grid,
    .other-measures-grid,
    .alert-signs,
    .coordination-team {
        grid-template-columns: 1fr;
    }

    .flow-branches,
    .troponin-branches {
        grid-template-columns: 1fr;
    }

    .timeline-item {
        flex-direction: column;
        padding-left: var(--spacing-lg);
    }

    .timeline-item::before {
        left: 10px;
    }

    .phase-item {
        flex-direction: column;
        padding-left: var(--spacing-lg);
    }

    .phase-item::before {
        left: 10px;
    }

    .followup-item {
        flex-direction: column;
    }

    .drug-combination {
        flex-direction: column;
    }

    .plus-sign {
        transform: rotate(90deg);
    }

    .prolongation-criteria {
        grid-template-columns: 1fr;
    }

    .anticoag-timeline {
        flex-direction: column;
    }

    .anticoag-arrow {
        transform: rotate(90deg);
    }

    .section-header h2 {
        font-size: var(--font-size-2xl);
    }

    .modal-content {
        margin: 10% 5%;
        max-width: 90%;
    }
}

@media screen and (max-width: 480px) {
    :root {
        --spacing-xl: 2rem;
        --spacing-lg: 1.5rem;
    }

    .header h1 {
        font-size: var(--font-size-2xl);
        flex-direction: column;
    }

    .header h1 i {
        font-size: 2rem;
    }

    .subtitle {
        font-size: var(--font-size-base);
    }

    .flow-step {
        padding: var(--spacing-md);
    }

    .step-content h4 {
        font-size: var(--font-size-lg);
    }

    .detail-section {
        padding: var(--spacing-md);
    }

    .value-item.main-value .value-number {
        font-size: var(--font-size-3xl);
    }
}

/* ============================================
   Parcours de Soins Styles
   ============================================ */

/* Acteurs du parcours */
.pathway-overview {
    margin-bottom: var(--spacing-xl);
}

.actors-grid {
    display: grid;
    grid-template-columns: repeat(auto-fit, minmax(280px, 1fr));
    gap: var(--spacing-lg);
    margin-top: var(--spacing-lg);
}

.actor-card {
    padding: var(--spacing-lg);
    background: white;
    border-radius: var(--border-radius);
    box-shadow: var(--shadow-md);
    transition: all 0.3s ease;
    border-top: 4px solid;
}

.actor-card:hover {
    transform: translateY(-5px);
    box-shadow: var(--shadow-lg);
}

.patient-actor {
    border-top-color: #667eea;
}

.medecin-actor {
    border-top-color: #10b981;
}

.urgences-actor {
    border-top-color: #ef4444;
}

.cardio-garde-actor {
    border-top-color: #f59e0b;
}

.cardio-ref-actor {
    border-top-color: #3b82f6;
}

.coro-actor {
    border-top-color: #8b5cf6;
}

.actor-icon {
    width: 60px;
    height: 60px;
    display: flex;
    align-items: center;
    justify-content: center;
    border-radius: 50%;
    margin-bottom: var(--spacing-md);
    font-size: 1.5rem;
    color: white;
}

.patient-actor .actor-icon {
    background: linear-gradient(135deg, #667eea, #764ba2);
}

.medecin-actor .actor-icon {
    background: linear-gradient(135deg, #10b981, #059669);
}

.urgences-actor .actor-icon {
    background: linear-gradient(135deg, #ef4444, #dc2626);
}

.cardio-garde-actor .actor-icon {
    background: linear-gradient(135deg, #f59e0b, #d97706);
}

.cardio-ref-actor .actor-icon {
    background: linear-gradient(135deg, #3b82f6, #2563eb);
}

.coro-actor .actor-icon {
    background: linear-gradient(135deg, #8b5cf6, #7c3aed);
}

.actor-card h4 {
    color: var(--text-primary);
    font-size: var(--font-size-lg);
    margin-bottom: var(--spacing-sm);
}

.actor-card p {
    color: var(--text-secondary);
    font-size: var(--font-size-sm);
    margin-bottom: var(--spacing-md);
    font-style: italic;
}

.actor-card ul {
    list-style: none;
    padding: 0;
}

.actor-card ul li {
    padding: var(--spacing-xs) 0;
    font-size: var(--font-size-sm);
    color: var(--text-secondary);
    display: flex;
    align-items: flex-start;
}

.actor-card ul li:before {
    content: "✓";
    margin-right: var(--spacing-xs);
    color: var(--success-color);
    font-weight: bold;
}

/* Flowchart du parcours */
.pathway-flowchart {
    margin-top: var(--spacing-xl);
}

.pathway-scenario {
    margin-bottom: var(--spacing-xl);
    padding: var(--spacing-xl);
    background: linear-gradient(to bottom, #f9fafb, white);
    border-radius: var(--border-radius);
    border: 2px solid var(--border-color);
}

.scenario-title {
    color: var(--text-primary);
    font-size: var(--font-size-xl);
    margin-bottom: var(--spacing-lg);
    padding-bottom: var(--spacing-md);
    border-bottom: 2px solid var(--border-color);
    display: flex;
    align-items: center;
    gap: var(--spacing-sm);
}

.scenario-title i {
    color: var(--warning-color);
}

.pathway-flow {
    display: flex;
    flex-direction: column;
    gap: 0;
}

.pathway-step {
    position: relative;
    padding: var(--spacing-lg);
    background: white;
    border-radius: var(--border-radius);
    box-shadow: var(--shadow-md);
    border-left: 5px solid;
}

.pathway-step.patient-step {
    border-left-color: #667eea;
}

.pathway-step.urgences-step {
    border-left-color: #ef4444;
}

.pathway-step.cardio-garde-step {
    border-left-color: #f59e0b;
}

.pathway-step.coro-step {
    border-left-color: #8b5cf6;
}

.pathway-step.hospital-step {
    border-left-color: #3b82f6;
}

.pathway-step.cardio-ref-step {
    border-left-color: #10b981;
}

.pathway-step.medecin-step {
    border-left-color: #06b6d4;
}

.step-number {
    position: absolute;
    top: -15px;
    left: 20px;
    width: 40px;
    height: 40px;
    background: linear-gradient(135deg, #667eea, #764ba2);
    color: white;
    border-radius: 50%;
    display: flex;
    align-items: center;
    justify-content: center;
    font-weight: bold;
    font-size: var(--font-size-lg);
    box-shadow: var(--shadow-md);
    z-index: 1;
}

.step-content h5 {
    color: var(--text-primary);
    font-size: var(--font-size-lg);
    margin-bottom: var(--spacing-md);
    display: flex;
    align-items: center;
    gap: var(--spacing-sm);
}

.step-content h5 i {
    color: var(--primary-color);
}

.step-content p strong {
    color: var(--text-primary);
    display: block;
    margin-bottom: var(--spacing-sm);
}

.step-content ul {
    list-style: none;
    padding-left: 0;
    margin: var(--spacing-md) 0;
}

.step-content ul li {
    padding: var(--spacing-xs) 0;
    padding-left: 1.5rem;
    position: relative;
    color: var(--text-secondary);
    font-size: var(--font-size-sm);
}

.step-content ul li:before {
    content: "→";
    position: absolute;
    left: 0;
    color: var(--primary-color);
    font-weight: bold;
}

.action-box {
    margin-top: var(--spacing-md);
    padding: var(--spacing-md);
    border-radius: var(--border-radius-sm);
    font-weight: 600;
    text-align: center;
    display: flex;
    align-items: center;
    justify-content: center;
    gap: var(--spacing-xs);
}

.action-box.alert {
    background: linear-gradient(135deg, #ef4444, #dc2626);
    color: white;
}

.action-box.urgent {
    background: linear-gradient(135deg, #f59e0b, #d97706);
    color: white;
}

.action-box.critical {
    background: linear-gradient(135deg, #dc2626, #991b1b);
    color: white;
    animation: pulse 2s infinite;
}

.action-box.warning {
    background: linear-gradient(135deg, #fbbf24, #f59e0b);
    color: #78350f;
}

.action-box.info {
    background: linear-gradient(135deg, #60a5fa, #3b82f6);
    color: white;
}

@keyframes pulse {
    0%, 100% { opacity: 1; }
    50% { opacity: 0.8; }
}

.pathway-arrow {
    display: flex;
    flex-direction: column;
    align-items: center;
    padding: var(--spacing-md) 0;
    position: relative;
}

.pathway-arrow i {
    font-size: 2rem;
    color: var(--primary-color);
    animation: bounce 2s infinite;
}

@keyframes bounce {
    0%, 100% { transform: translateY(0); }
    50% { transform: translateY(10px); }
}

.time-label {
    margin-top: var(--spacing-xs);
    padding: 4px 12px;
    background-color: var(--primary-color);
    color: white;
    border-radius: 12px;
    font-size: var(--font-size-xs);
    font-weight: 600;
}

.decision-tree {
    display: grid;
    grid-template-columns: repeat(auto-fit, minmax(250px, 1fr));
    gap: var(--spacing-lg);
    margin-top: var(--spacing-md);
}

.decision-branch {
    padding: var(--spacing-md);
    background: var(--bg-secondary);
    border-radius: var(--border-radius-sm);
    border: 2px solid var(--border-color);
}

.decision-branch.stemi-branch {
    border-color: var(--danger-color);
    background: linear-gradient(to bottom, #fee2e2, white);
}

.decision-branch.nstemi-branch {
    border-color: var(--warning-color);
    background: linear-gradient(to bottom, #fef3c7, white);
}

.decision-branch .badge {
    display: inline-block;
    margin-bottom: var(--spacing-sm);
}

.decision-branch p {
    font-size: var(--font-size-sm);
    color: var(--text-secondary);
    margin: var(--spacing-sm) 0;
}

.time-target {
    font-weight: 600;
    color: var(--primary-color);
    font-size: var(--font-size-sm);
}

.procedure-steps {
    display: flex;
    flex-direction: column;
    gap: var(--spacing-sm);
    margin: var(--spacing-md) 0;
}

.sub-step {
    display: flex;
    align-items: center;
    gap: var(--spacing-sm);
    padding: var(--spacing-sm);
    background: var(--bg-secondary);
    border-radius: var(--border-radius-sm);
    font-size: var(--font-size-sm);
    color: var(--text-secondary);
}

.sub-step i {
    color: var(--primary-color);
    width: 20px;
}

.medication-box,
.discharge-box,
.follow-up-box,
.alert-box,
.decision-box {
    margin-top: var(--spacing-md);
    padding: var(--spacing-md);
    border-radius: var(--border-radius-sm);
    font-size: var(--font-size-sm);
}

.medication-box {
    background: linear-gradient(to right, #dbeafe, white);
    border-left: 3px solid var(--info-color);
}

.discharge-box {
    background: linear-gradient(to right, #d1fae5, white);
    border-left: 3px solid var(--success-color);
}

.follow-up-box {
    background: linear-gradient(to right, #e0e7ff, white);
    border-left: 3px solid var(--primary-color);
}

.alert-box {
    background: linear-gradient(to right, #fee2e2, white);
    border-left: 3px solid var(--danger-color);
}

.decision-box {
    background: linear-gradient(to right, #fef3c7, white);
    border-left: 3px solid var(--warning-color);
}

.medication-box strong,
.discharge-box strong,
.follow-up-box strong,
.alert-box strong,
.decision-box strong {
    display: block;
    margin-bottom: var(--spacing-sm);
    color: var(--text-primary);
}

.medication-box ul,
.discharge-box ul {
    list-style: none;
    padding-left: 0;
    margin-top: var(--spacing-sm);
}

.medication-box ul li,
.discharge-box ul li {
    padding: 4px 0;
    color: var(--text-secondary);
}

/* Parcours consultation programmée */
.scheduled-pathway {
    background: linear-gradient(to bottom, #f0fdf4, white);
    border: 2px solid #10b981;
}

.scheduled-flow {
    flex-direction: row;
    flex-wrap: wrap;
    justify-content: center;
    align-items: center;
}

.scheduled-flow .pathway-step {
    flex: 0 0 calc(25% - var(--spacing-md));
    min-width: 200px;
}

.pathway-arrow-horizontal {
    flex: 0 0 auto;
    padding: 0 var(--spacing-sm);
}

.pathway-arrow-horizontal i {
    font-size: 2rem;
    color: var(--success-color);
}

/* Points clés */
.pathway-key-points {
    margin-top: var(--spacing-xl);
    padding: var(--spacing-xl);
    background: linear-gradient(135deg, #667eea 0%, #764ba2 100%);
    border-radius: var(--border-radius);
    color: white;
}

.pathway-key-points h3 {
    color: white;
    margin-bottom: var(--spacing-lg);
}

.key-points-grid {
    display: grid;
    grid-template-columns: repeat(auto-fit, minmax(250px, 1fr));
    gap: var(--spacing-lg);
}

.key-point-card {
    background: white;
    padding: var(--spacing-lg);
    border-radius: var(--border-radius);
    box-shadow: var(--shadow-lg);
}

.point-icon {
    width: 50px;
    height: 50px;
    display: flex;
    align-items: center;
    justify-content: center;
    border-radius: 50%;
    margin-bottom: var(--spacing-md);
    font-size: 1.5rem;
    color: white;
}

.point-icon.speed {
    background: linear-gradient(135deg, #fbbf24, #f59e0b);
}

.point-icon.coordination {
    background: linear-gradient(135deg, #3b82f6, #2563eb);
}

.point-icon.continuity {
    background: linear-gradient(135deg, #10b981, #059669);
}

.point-icon.education {
    background: linear-gradient(135deg, #8b5cf6, #7c3aed);
}

.key-point-card h4 {
    color: var(--text-primary);
    font-size: var(--font-size-lg);
    margin-bottom: var(--spacing-md);
}

.key-point-card ul {
    list-style: none;
    padding: 0;
}

.key-point-card ul li {
    padding: var(--spacing-xs) 0;
    font-size: var(--font-size-sm);
    color: var(--text-secondary);
    display: flex;
    align-items: flex-start;
}

.key-point-card ul li:before {
    content: "✓";
    margin-right: var(--spacing-xs);
    color: var(--success-color);
    font-weight: bold;
}

/* Contacts d'urgence */
.emergency-contacts {
    margin-top: var(--spacing-xl);
}

.contacts-grid {
    display: grid;
    grid-template-columns: repeat(auto-fit, minmax(250px, 1fr));
    gap: var(--spacing-lg);
    margin-top: var(--spacing-lg);
}

.contact-card {
    padding: var(--spacing-lg);
    background: white;
    border-radius: var(--border-radius);
    box-shadow: var(--shadow-md);
    text-align: center;
    transition: transform 0.3s ease;
}

.contact-card:hover {
    transform: translateY(-5px);
    box-shadow: var(--shadow-lg);
}

.contact-card.emergency {
    background: linear-gradient(to bottom, #fee2e2, white);
    border: 2px solid var(--danger-color);
}

.contact-card.cardio {
    background: linear-gradient(to bottom, #dbeafe, white);
    border: 2px solid var(--info-color);
}

.contact-card.medecin {
    background: linear-gradient(to bottom, #d1fae5, white);
    border: 2px solid var(--success-color);
}

.contact-card.centre {
    background: linear-gradient(to bottom, #e0e7ff, white);
    border: 2px solid var(--primary-color);
}

.contact-card i {
    font-size: 2.5rem;
    margin-bottom: var(--spacing-md);
}

.contact-card.emergency i {
    color: var(--danger-color);
}

.contact-card.cardio i {
    color: var(--info-color);
}

.contact-card.medecin i {
    color: var(--success-color);
}

.contact-card.centre i {
    color: var(--primary-color);
}

.contact-card h4 {
    color: var(--text-primary);
    font-size: var(--font-size-lg);
    margin-bottom: var(--spacing-sm);
}

.phone-number {
    font-size: 1.5rem;
    font-weight: 700;
    color: var(--text-primary);
    margin: var(--spacing-md) 0;
}

.contact-card .description {
    font-size: var(--font-size-sm);
    color: var(--text-secondary);
}

/* Timeline infographique */
.timeline-infographic {
    margin-top: var(--spacing-xl);
    padding: var(--spacing-xl);
    background: var(--bg-secondary);
    border-radius: var(--border-radius);
}

.timeline-container {
    position: relative;
    padding: var(--spacing-xl) 0;
    margin-top: var(--spacing-lg);
}

.timeline-container::before {
    content: '';
    position: absolute;
    left: 30px;
    top: 0;
    bottom: 0;
    width: 4px;
    background: linear-gradient(to bottom, #667eea, #10b981);
}

.timeline-item {
    position: relative;
    padding-left: 80px;
    margin-bottom: var(--spacing-xl);
}

.timeline-item:last-child {
    margin-bottom: 0;
}

.timeline-marker {
    position: absolute;
    left: 0;
    width: 60px;
    height: 60px;
    border-radius: 50%;
    background: linear-gradient(135deg, #667eea, #764ba2);
    display: flex;
    align-items: center;
    justify-content: center;
    color: white;
    font-weight: bold;
    font-size: var(--font-size-xs);
    box-shadow: var(--shadow-lg);
    z-index: 1;
}

.timeline-item.critical .timeline-marker {
    background: linear-gradient(135deg, #ef4444, #dc2626);
    animation: pulse 2s infinite;
    width: 70px;
    height: 70px;
    left: -5px;
}

.timeline-content {
    background: white;
    padding: var(--spacing-md);
    border-radius: var(--border-radius);
    box-shadow: var(--shadow-md);
}

.timeline-content h5 {
    color: var(--text-primary);
    font-size: var(--font-size-lg);
    margin-bottom: var(--spacing-xs);
}

.timeline-content p {
    color: var(--text-secondary);
    font-size: var(--font-size-sm);
}

/* Responsive pour parcours */
@media (max-width: 768px) {
    .actors-grid {
        grid-template-columns: 1fr;
    }
    
    .scheduled-flow {
        flex-direction: column;
    }
    
    .scheduled-flow .pathway-step {
        flex: 1 1 100%;
    }
    
    .pathway-arrow-horizontal {
        transform: rotate(90deg);
        padding: var(--spacing-md) 0;
    }
    
    .key-points-grid {
        grid-template-columns: 1fr;
    }
    
    .contacts-grid {
        grid-template-columns: 1fr;
    }
    
    .decision-tree {
        grid-template-columns: 1fr;
    }
    
    .timeline-container::before {
        left: 15px;
    }
    
    .timeline-item {
        padding-left: 60px;
    }
    
    .timeline-marker {
        width: 40px;
        height: 40px;
        font-size: 0.6rem;
    }
    
    .timeline-item.critical .timeline-marker {
        width: 50px;
        height: 50px;
        left: -5px;
    }
}

/* ============================================
   Print Styles
   ============================================ */
@media print {
    .header,
    .main-nav,
    .footer,
    .btn-expand,
    .btn-collapse {
        display: none;
    }

    .section {
        display: block !important;
        page-break-before: always;
    }

    .detail-section.collapsed {
        max-height: none;
        opacity: 1;
    }

    body {
        background-color: white;
    }

    .section-header {
        border-bottom-color: black;
    }
}

/* ============================================
   Accessibility
   ============================================ */
*:focus {
    outline: 2px solid var(--primary-color);
    outline-offset: 2px;
}

.visually-hidden {
    position: absolute;
    width: 1px;
    height: 1px;
    padding: 0;
    margin: -1px;
    overflow: hidden;
    clip: rect(0, 0, 0, 0);
    white-space: nowrap;
    border-width: 0;
}

/* ============================================
   Utility Classes
   ============================================ */
.text-center {
    text-align: center;
}

.text-primary {
    color: var(--primary-color);
}

.text-success {
    color: var(--success-color);
}

.text-warning {
    color: var(--warning-color);
}

.text-danger {
    color: var(--danger-color);
}

.mb-0 {
    margin-bottom: 0;
}

.mt-0 {
    margin-top: 0;
}

.hidden {
    display: none;
}

.show {
    display: block;
}